Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4152061 | 0.86 | ALDH1A1 (0.46) | CES2CES1DAOALDH1A1GAA | |
| SCHEMBL4160439 | 0.84 | TSHR (0.46) | CES2CES1ALDH1A1GAASLC18A3 | |
| SCHEMBL621714 | 0.82 | ALDH1A1 (0.58) | CES2CES1DAOALDH1A1GAA | |
| SCHEMBL229300 | 0.82 | ALDH1A1 (0.51) | CES2CES1DAOALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL228752 | 0.81 | ALDH1A1 (0.50) | CES2CES1DAOALDH1A1GAA | |
| Bromide SCHEMBL10964629 | 0.81 | ALDH1A1 (0.50) | CES2CES1DAOALDH1A1GAA | |
| SCHEMBL7005733 | 0.79 | TSHR (0.57) | CES2CES1DAOALDH1A1GAA | |
| SCHEMBL5046057 | 0.78 | RAB9A (0.58) | CES2CES1DAOALDH1A1GAA | |
| SCHEMBL9777027 | 0.78 | RAB9A (0.58) | CES2CES1DAOALDH1A1GAA | |
| SCHEMBL4673525 | 0.75 | ALDH1A1 (0.51) | CES2CES1DAOALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2592933-B1 | MIF INHIBITORS AND THEIR USES | GAWECO ANDERSON (US) | 2017-04-05 | — | — | EP | disclosed |
| EP-2592933-B1 | MIF INHIBITORS AND THEIR USES | GAWECO ANDERSON (US) | 2017-04-05 | — | — | EP | disclosed |
| US-9050334-B2 | MIF inhibitors and their uses | INNOV88 LLC (US) | 2015-06-09 | — | — | US | disclosed |
| US-9050334-B2 | MIF inhibitors and their uses | INNOV88 LLC (US) | 2015-06-09 | — | — | US | disclosed |
| US-9050334-B2 | MIF inhibitors and their uses | INNOV88 LLC (US) | 2015-06-09 | — | — | US | disclosed |
| EP-2592933-A1 | MIF INHIBITORS AND THEIR USES | Gaweco, Anderson (US) | 2013-05-22 | — | — | EP | disclosed |
| US-20120035150-A1 | MIF INHIBITORS AND THEIR USES | INNOV88 LLC | 2012-02-09 | — | — | US | disclosed |
| US-20120035150-A1 | MIF INHIBITORS AND THEIR USES | INNOV88 LLC | 2012-02-09 | — | — | US | disclosed |
| US-20120035150-A1 | MIF INHIBITORS AND THEIR USES | INNOV88 LLC | 2012-02-09 | — | — | US | disclosed |
| WO-2012009649-A1 | MIF INHIBITORS AND THEIR USES | GAWECO ANDERSON (US) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012009649-A1 | MIF INHIBITORS AND THEIR USES | GAWECO ANDERSON (US) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035150-A1 | MIF INHIBITORS AND THEIR USES | MIF, SERPINB1, HMGB2 | CES2 3235/4885CES1 768/4885DAO 3770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.