Sugi Predict

Sugi Predict / Compounds / SCHEMBL357203

SCHEMBL357203

SCHEMBL357203

CC(C)(C)OC(=O)c1ccc([N+](=O)[O-])c(F)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ATM Q13315 1/20 0.47
▸ TDP1 Q9NUW8 1/20 0.47
▸ VCAM1 P19320 1/20 0.45
▸ MET P08581 1/20 0.43
▸ TSHR P16473 2/20 0.42
▸ NPSR1 Q6W5P4 2/20 0.41
▸ HPGD P15428 2/20 0.41
▸ ALDH1A1 P00352 1/20 0.41
▸ ITGB1 P05556 1/20 0.41
▸ ITGA5 P08648 1/20 0.41
▸ CASP6 P55212 1/20 0.41
▸ CA12 O43570 1/20 0.41
▸ CA1 P00915 1/20 0.41
▸ CA2 P00918 1/20 0.41
▸ CA9 Q16790 1/20 0.41
▸ CA14 Q9ULX7 1/20 0.41
▸ MAPT P10636 3/20 0.41
▸ NPC1 O15118 1/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ CTSK P43235 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29966142 1.00 ATM (0.47) ATMTDP1VCAM1METTSHR
SCHEMBL1570007 0.88 ITGB1 (0.53) VCAM1METTSHRNPSR1HPGD
SCHEMBL11247732 0.86 CASP6 (0.57) VCAM1METTSHRNPSR1HPGD
SCHEMBL25484994 0.84 GPR35 (0.47) VCAM1METTSHRNPSR1HPGD
SCHEMBL1027488 0.84 TSHR (0.62) VCAM1TSHRALDH1A1MAPTNPC1
SCHEMBL557153 0.84 VCAM1 (0.46) ATMTDP1VCAM1METTSHR
SCHEMBL29556186 0.83 VCAM1 (0.58) ATMTDP1VCAM1NPSR1HPGD
SCHEMBL5934 0.83 VCAM1 (0.58) ATMTDP1VCAM1NPSR1HPGD
SCHEMBL15292815 0.82 VCAM1 (0.45) VCAM1METTSHRNPSR1HPGD
SCHEMBL28824450 0.81 ATM (0.41) ATMTDP1VCAM1METTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 125 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12611401-B2 Combinations comprising benzodioxol as GLP-1R agonists for use in the treatment of NASH/NAFLD and related diseases PFIZER INC. (US) 2026-04-28 — — US disclosed
EP-4271674-B9 CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES INC (US) 2026-03-11 — — EP disclosed
US-12570642-B2 GLP-IR modulating compounds GILEAD SCIENCES, INC. (US) 2026-03-10 — — US disclosed
EP-4691554-A2 GLP-1R MODULATING COMPOUNDS Gilead Sciences, Inc. (US) 2026-02-11 — — EP disclosed
US-20260035362-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC (CN) 2026-02-05 — — US disclosed
US-12497382-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2025-12-16 — — US disclosed
EP-4271674-B3 CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES INC (US) 2025-12-03 — — EP disclosed
EP-4271672-B1 CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES INC (US) 2025-12-03 — — EP disclosed
US-20250340544-A1 GLP-1 Receptor Agonists and Uses Thereof PFIZER INC. (US) 2025-11-06 — — US disclosed
US-20250312352-A1 GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2025-10-09 — — US disclosed
US-6903115-B2 Bipiperidine compounds ASTRAZENECA AB (SE) 2005-06-07 — — US disclosed
EP-1493743-A1 Substituted bipiperidine intermediates and derivatives thereof AstraZeneca AB (SE) 2005-01-05 — — EP disclosed
US-20040014783-A1 Chemical compounds ASTRAZENECA AB, A SWEDEN CORPORATION 2004-01-22 — — US disclosed
US-20040006080-A1 Chemical compounds ASTRAZENECA AB, A SWEDEN CORPORATION 2004-01-08 — — US disclosed
US-6525070-B2 For therapy of chemokine (such as CCR3) or H1 mediated disease state ASTRAZENECA AB (SE) 2003-02-25 — — US disclosed
EP-1274701-A1 CHEMICAL COMPOUNDS AstraZeneca AB (SE) 2003-01-15 — — EP disclosed
US-20020077337-A1 Chemical compounds ASTRAZENECA AB (SE) 2002-06-20 — — US disclosed
WO-2001077101-A1 CHEMICAL COMPOUNDS ASTRAZENECA AB (SE) 2001-10-18 — — WO disclosed
WO-1997033872-A1 ANTI-VIRAL 4-ACYLAMINO-3-[IMIDAZOL-I-YL]-BENZOIC ACID DERIVATIVES BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) 1997-09-18 — — WO disclosed
US-5141627-A Calcium concentration of blood THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1992-08-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035362-A1 GLP-1R AGONISTS AND USES THEREOF GLP1R, GPR119, IAPP ATM 2247/4885TDP1 3606/4885VCAM1 423/4885
US-20020077337-A1 Chemical compounds CCR3, CCR1, CCR4 ATM 3729/4885TDP1 4641/4885VCAM1 101/4885
US-20250312352-A1 GLP-1R MODULATING COMPOUNDS GLP1R, GIPR, GPR119 ATM 4056/4885TDP1 3351/4885VCAM1 1203/4885
US-20250340544-A1 GLP-1 Receptor Agonists and Uses Thereof GLP1R, GIPR, GCGR ATM 4212/4885TDP1 3599/4885VCAM1 1577/4885
US-20040006080-A1 Chemical compounds CCR3, CCR1, CCR4 ATM 3729/4885TDP1 4641/4885VCAM1 101/4885
US-12611401-B2 Combinations comprising benzodioxol as GLP-1R agonists for use in the treatment of NASH/NAFLD and related diseases GLP1R, GCKR, GPR119 ATM 2365/4885TDP1 4430/4885VCAM1 1878/4885
US-12570642-B2 GLP-IR modulating compounds GLP1R, GIPR, GPR119 ATM 2319/4885TDP1 4337/4885VCAM1 1524/4885
US-20040014783-A1 Chemical compounds CCR3, CCR1, CCR4 ATM 3729/4885TDP1 4641/4885VCAM1 101/4885
US-12497382-B2 GLP-1R modulating compounds GLP1R, GIPR, GPR119 ATM 4056/4885TDP1 3351/4885VCAM1 1203/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.