Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3625164 | 0.82 | TDP2 (0.40) | TDP2MAPK1LMNAGAASMYD3 | |
| SCHEMBL3582037 | 0.80 | SRD5A2 (0.55) | MAPK1LMNAGAAPOLBSRD5A2 | |
| SCHEMBL3582033 | 0.80 | SRD5A2 (0.55) | MAPK1LMNAGAAPOLBSRD5A2 | |
| SCHEMBL3573881 | 0.78 | SMYD3 (0.55) | TDP2SMYD3CA9CRBN | |
| SCHEMBL3579843 | 0.73 | TDP2 (0.58) | TDP2MAPK1LMNAGAASMYD3 | |
| SCHEMBL7681995 | 0.72 | MAPK1 (0.62) | MAPK1LMNAPOLBMAPTALDH1A1 | |
| SCHEMBL7681987 | 0.72 | MAPK1 (0.62) | MAPK1LMNAPOLBMAPTALDH1A1 | |
| SCHEMBL7679044 | 0.69 | SMYD3 (0.53) | TDP2GAASMYD3ALDH1A1TDP1 | |
| SCHEMBL3573876 | 0.69 | SMYD3 (0.56) | TDP2SMYD3CRBN | |
| SCHEMBL7047455 | 0.69 | ALOX15 (0.54) | MAPK1LMNAGAAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7692005-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2010-04-06 | — | — | US | disclosed |