Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 4/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 3/20 | 0.55 |
| ▸ | PPARA | Q07869 | 3/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | PPARD | Q03181 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL360368 | 1.00 | MAOB (0.57) | MAOBLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL13643125 | 0.88 | LTA4H (0.60) | MAOBLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL19143273 | 0.85 | MAOB (0.52) | MAOBLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL9845668 | 0.84 | CYP4F2 (0.60) | MAOBBCHE | |
| SCHEMBL11440388 | 0.84 | MAOB (0.60) | MAOBLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL4243613 | 0.83 | LMNA (0.59) | MAOBLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL9637755 | 0.83 | MAOB (0.59) | MAOBLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL13643128 | 0.83 | MAOB (0.64) | MAOBLTA4HPPARGPPARAFFAR1 | |
| SCHEMBL2736160 | 0.83 | LTA4H (0.61) | MAOBLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL358058 | 0.82 | TRPA1 (0.65) | SLC6A2SLC6A3SIGMAR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013211-B1 | PURINE DERIVATIVES FOR USE AS ADENOSIN A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2012-03-14 | — | — | EP | disclosed |