Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.37 |
| ▸ | ESRRG | P62508 | 2/20 | 0.37 |
| ▸ | ESRRB | O95718 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3571051 | 0.94 | NR1H4 (0.37) | CYP51A1NR1H4TRPV1ESRRGESRRB | |
| SCHEMBL3575452 | 0.89 | KMT2A (0.42) | NR1H4ESRRGESRRBSIGMAR1HSP90AA1 | |
| SCHEMBL9957841 | 0.88 | ESRRG (0.39) | CYP51A1NR1H4TRPV1ESRRGESRRB | |
| SCHEMBL3574044 | 0.88 | NR1H4 (0.37) | NR1H4ESRRGESRRBSIGMAR1HSP90AA1 | |
| SCHEMBL3576126 | 0.87 | CYP2C19 (0.37) | KDM4CCYP51A1NR1H4TRPV1ESRRG | |
| SCHEMBL3579634 | 0.87 | SERPINE1 (0.40) | NR1H4ESRRGESRRBSIGMAR1HSP90AA1 | |
| SCHEMBL3577133 | 0.86 | CYP51A1 (0.36) | CYP51A1NR1H4TRPV1ESRRGESRRB | |
| SCHEMBL3572359 | 0.86 | TRPV1 (0.37) | NR1H4TRPV1ESRRGESRRBROCK2 | |
| SCHEMBL3580658 | 0.84 | RAF1 (0.39) | NR1H4ESRRGESRRBSIGMAR1HSP90AA1 | |
| SCHEMBL3576692 | 0.82 | ESRRG (0.37) | NR1H4TRPV1ESRRGESRRBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |