Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | CCR9 | P51686 | 2/20 | 0.37 |
| ▸ | ESRRG | P62508 | 2/20 | 0.36 |
| ▸ | ESRRB | O95718 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580029 | 0.90 | MLYCD (0.34) | SIGMAR1HSP90AA1OPRM1OPRD1 | |
| SCHEMBL1397709 | 0.89 | OPRM1 (0.35) | CCR9SIGMAR1OPRM1OPRD1 | |
| SCHEMBL3574429 | 0.88 | KDM4C (0.39) | NR1H4ESRRGESRRBSIGMAR1HSP90AA1 | |
| SCHEMBL3579370 | 0.87 | SLC2A1 (0.39) | TRPM8 | |
| SCHEMBL3571051 | 0.86 | NR1H4 (0.37) | NR1H4ESRRGESRRBSIGMAR1HSP90AA1 | |
| SCHEMBL3579634 | 0.86 | SERPINE1 (0.40) | NR1H4CCR9ESRRGESRRBSIGMAR1 | |
| SCHEMBL12520875 | 0.85 | TRPM8 (0.40) | NR1H4CCR9ESRRGESRRBOPRM1 | |
| SCHEMBL3575452 | 0.85 | KMT2A (0.42) | NR1H4ESRRGESRRBSIGMAR1HSP90AA1 | |
| SCHEMBL3584245 | 0.84 | SIGMAR1 (0.34) | SIGMAR1OPRM1OPRD1 | |
| SCHEMBL3576692 | 0.83 | ESRRG (0.37) | NR1H4CCR9ESRRGESRRBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |