Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.37 |
| ▸ | ESRRG | P62508 | 3/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | ESRRB | O95718 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9957841 | 0.90 | ESRRG (0.39) | CYP2C19ROCK2CYP51A1ESRRGNR1H4 | |
| SCHEMBL3574429 | 0.87 | KDM4C (0.39) | ROCK2CYP51A1ESRRGNR1H4ESRRB | |
| SCHEMBL3571051 | 0.87 | NR1H4 (0.37) | ROCK2CYP51A1ESRRGNR1H4ESRRB | |
| SCHEMBL3572359 | 0.84 | TRPV1 (0.37) | ROCK2ESRRGNR1H4ESRRBOPRM1 | |
| SCHEMBL3577133 | 0.84 | CYP51A1 (0.36) | ROCK2CYP51A1ESRRGNR1H4ESRRB | |
| SCHEMBL3582883 | 0.83 | RAF1 (0.40) | CYP2C19ESRRGNR1H4ESRRBOPRM1 | |
| SCHEMBL3578664 | 0.82 | CYP2C19 (0.39) | CYP2C19ESRRGNR1H4ESRRBOPRM1 | |
| SCHEMBL3581265 | 0.81 | NR1H4 (0.39) | CYP2C19ESRRGNR1H4ESRRBOPRM1 | |
| SCHEMBL3573203 | 0.80 | RAF1 (0.40) | CYP2C19ESRRGNR1H4ESRRBOPRM1 | |
| SCHEMBL9958256 | 0.80 | NR1H4 (0.38) | ESRRGNR1H4ESRRBOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |