Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | ESRRG | P62508 | 2/20 | 0.35 |
| ▸ | ESRRB | O95718 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3571051 | 0.92 | NR1H4 (0.37) | CYP51A1NR1H4TRPV1HSP90AA1ESRRG | |
| SCHEMBL3572359 | 0.89 | TRPV1 (0.37) | NR1H4TRPV1ESRRGESRRBOPRM1 | |
| SCHEMBL9957841 | 0.88 | ESRRG (0.39) | CYP51A1NR1H4TRPV1HSP90AA1ESRRG | |
| SCHEMBL3574429 | 0.86 | KDM4C (0.39) | CYP51A1NR1H4TRPV1HSP90AA1ESRRG | |
| SCHEMBL3576126 | 0.84 | CYP2C19 (0.37) | CYP51A1NR1H4TRPV1HSP90AA1ESRRG | |
| SCHEMBL3585932 | 0.82 | CCR9 (0.36) | NR1H4HSP90AA1ESRRGESRRBOPRM1 | |
| SCHEMBL3576645 | 0.81 | HSP90AA1 (0.37) | NR1H4HSP90AA1ESRRGESRRBOPRM1 | |
| SCHEMBL3583608 | 0.81 | ESRRG (0.35) | NR1H4HSP90AA1ESRRGESRRBOPRM1 | |
| SCHEMBL3575573 | 0.81 | HSP90AA1 (0.36) | NR1H4HSP90AA1ESRRGESRRBOPRM1 | |
| SCHEMBL3578408 | 0.80 | TRPV1 (0.40) | TRPV1ESRRGESRRBROCK2RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |