Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | ESRRG | P62508 | 3/20 | 0.39 |
| ▸ | ESRRB | O95718 | 1/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3578799 | 0.91 | TP53 (0.39) | KMT2AOPRM1OPRD1NR1H4PPARG | |
| SCHEMBL3570707 | 0.91 | C5AR1 (0.39) | KMT2AOPRM1OPRD1NR1H4PPARG | |
| SCHEMBL3574429 | 0.89 | KDM4C (0.39) | OPRM1OPRD1NR1H4ESRRGESRRB | |
| SCHEMBL3579634 | 0.89 | SERPINE1 (0.40) | KMT2AMEN1NR1H4ESRRGESRRB | |
| SCHEMBL3587595 | 0.89 | C5AR1 (0.49) | KMT2AMEN1OPRM1OPRD1NR1H4 | |
| SCHEMBL3580658 | 0.89 | RAF1 (0.39) | KMT2AMEN1OPRM1OPRD1NR1H4 | |
| SCHEMBL3571051 | 0.87 | NR1H4 (0.37) | OPRM1OPRD1NR1H4ESRRGESRRB | |
| SCHEMBL3573203 | 0.85 | RAF1 (0.40) | KMT2AMEN1OPRM1OPRD1NR1H4 | |
| SCHEMBL3574044 | 0.85 | NR1H4 (0.37) | OPRM1OPRD1NR1H4ESRRGESRRB | |
| SCHEMBL3582883 | 0.84 | RAF1 (0.40) | KMT2AMEN1OPRM1OPRD1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |