Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | USP2 | O75604 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3574801 | 1.00 | TSHR (0.71) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL13539640 | 0.86 | TSHR (0.72) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL3416007 | 0.85 | TSHR (0.66) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL3416005 | 0.85 | TSHR (0.66) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL8976337 | 0.83 | SMN1; SMN2 (0.68) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL8976340 | 0.83 | SMN1; SMN2 (0.68) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL13306991 | 0.83 | TSHR (0.64) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL13499548 | 0.83 | ALDH1A1 (0.73) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL27347843 | 0.82 | TSHR (0.67) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL13499253 | 0.82 | TSHR (0.62) | TSHRUSP2ALOX15SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029620-A1 | SUBSTITUTED TRIAZOLINE, TETRAZOLONE AND IMIDAZOLONE DERIVATIVES FOR USE AS A MEDICINE | JANSSEN PHARMACEUTICA N.V. | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029620-A1 | SUBSTITUTED TRIAZOLINE, TETRAZOLONE AND IMIDAZOLONE DERIVATIVES FOR USE AS A MEDICINE | ADRA2C, ADRB2, CHRNA5 | TSHR 937/4885USP2 4507/4885ALOX15 1742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.