Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3416005 | 1.00 | TSHR (0.66) | TSHRUSP2ALOX15SMN1; SMN2KDM4E | |
| SCHEMBL3574805 | 0.85 | TSHR (0.71) | TSHRUSP2ALOX15SMN1; SMN2KDM4E | |
| SCHEMBL3574801 | 0.85 | TSHR (0.71) | TSHRUSP2ALOX15SMN1; SMN2KDM4E | |
| SCHEMBL3414767 | 0.84 | USP2 (0.48) | TSHRUSP2ALOX15SMN1; SMN2KDM4E | |
| SCHEMBL3414770 | 0.84 | USP2 (0.48) | TSHRUSP2ALOX15SMN1; SMN2KDM4E | |
| SCHEMBL13539640 | 0.82 | TSHR (0.72) | TSHRUSP2ALOX15SMN1; SMN2KDM4E | |
| SCHEMBL27374583 | 0.81 | SIGMAR1 (0.46) | TSHRUSP2ALOX15SMN1; SMN2KDM4E | |
| SCHEMBL9564607 | 0.80 | LMNA (0.48) | TSHRUSP2ALOX15SMN1; SMN2KDM4E | |
| SCHEMBL8976340 | 0.79 | SMN1; SMN2 (0.68) | TSHRUSP2ALOX15SMN1; SMN2KDM4E | |
| SCHEMBL13306991 | 0.79 | TSHR (0.64) | TSHRUSP2ALOX15SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554286-B1 | FUSED HETEROCYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-27 | — | — | EP | disclosed |
| CN-100522972-C | Fused heterocyclic isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA NV (BE) | 2009-08-05 | — | — | CN | disclosed |
| US-7501418-B2 | e.g. 3-[4-(2-Methyl-3-phenyl-allyl)-piperazin-1-ylmethyl]-3a,4-dihydro-3H-2,5-dioxa-1,7-diaza-dicyclopenta[a,g]naphthalene; serotonine (5-HT) reuptake inhibitor, alpha 2-adrenoceptor antagonist; antidepressant, anxiolytic agent; Parkinson's disease, eating disorders, psychosis, obesity | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-03-10 | — | — | US | disclosed |
| US-7462717-B2 | C6-and C9-substituted chromeno[4,3-c]isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-09 | — | — | US | disclosed |
| CN-100400540-C | Isoxazoline derivatives as anti-depressants | JANSSEN PHARMACEUTICA NV (BE) | 2008-07-09 | — | — | CN | disclosed |
| EP-1532155-B1 | C6- AND C9-SUBSTITUTED CHROMENO[4,3-c]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-27 | — | — | EP | disclosed |
| CN-1303085-C | C6- and C9-substituted isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA NV (BE) | 2007-03-07 | — | — | CN | disclosed |
| US-7169786-B2 | Isoxazoline derivatives as anti-depressants | JANSSEN-CILAG S.A. (ES) | 2007-01-30 | — | — | US | disclosed |
| EP-1368358-B1 | ISOXAZOLINE DERIVATIVES AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2006-08-23 | — | — | EP | disclosed |
| US-20060122167-A1 | C6-and c9-substituted isoxazoline derivatives and their use as anti-depressants | JANSSEN-CILAG S.A. (ES) | 2006-06-08 | — | — | US | disclosed |
| US-20060116378-A1 | Fused heterocyclic isoxazoline derivatives and their use as anti-derpressants | JANSSEN-CILAG S.A. (ES) | 2006-06-01 | — | — | US | disclosed |
| CN-1675223-A | C6- and C9-substituted isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-28 | — | — | CN | disclosed |
| CN-1675224-A | fused heterocyclic isoxazoline derivatives and their use as antidepressants | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-28 | — | — | CN | disclosed |
| EP-1554286-A1 | FUSED HETEROCYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-07-20 | — | — | EP | disclosed |
| US-20040122037-A1 | Isoxazoline derivatives as anti-depressants | JANSSEN-CILAG S.A. (ES) | 2004-06-24 | — | — | US | disclosed |
| CN-1492871-A | Isoxazoline derivatives as anti-depressants | ղɭҩҵ����˾ | 2004-04-28 | — | — | CN | disclosed |
| WO-2004018483-A1 | FUSED HETEROCYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-03-04 | — | — | WO | disclosed |
| EP-1368358-A1 | ISOXAZOLINE DERIVATIVES AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002066484-A1 | ISOXAZOLINE DERIVATIVES AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122037-A1 | Isoxazoline derivatives as anti-depressants | HTR7, HTR1A, HTR2C | TSHR 224/4885USP2 3213/4885ALOX15 2100/4885 |
| US-20060122167-A1 | C6-and c9-substituted isoxazoline derivatives and their use as anti-depressants | HTR2C, HTR7, DRD4 | TSHR 293/4885USP2 3908/4885ALOX15 1489/4885 |
| US-20060116378-A1 | Fused heterocyclic isoxazoline derivatives and their use as anti-derpressants | PARK7, HTR7, TPH2 | TSHR 437/4885USP2 3720/4885ALOX15 419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.