Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | ESRRG | P62508 | 2/20 | 0.37 |
| ▸ | ESRRB | O95718 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580712 | 0.87 | NR1H4 (0.39) | CYP2C19NR1H4ESRRGESRRBMEN1 | |
| SCHEMBL3582883 | 0.85 | RAF1 (0.40) | CYP2C19NR1H4ESRRGESRRBMEN1 | |
| SCHEMBL3576126 | 0.82 | CYP2C19 (0.37) | CYP2C19NR1H4ESRRGESRRBMEN1 | |
| SCHEMBL9957841 | 0.79 | ESRRG (0.39) | CYP2C19NR1H4ESRRGESRRBMEN1 | |
| SCHEMBL3581265 | 0.78 | NR1H4 (0.39) | CYP2C19NR1H4ESRRGESRRBMEN1 | |
| SCHEMBL3573203 | 0.78 | RAF1 (0.40) | CYP2C19NR1H4ESRRGESRRBMEN1 | |
| SCHEMBL12521166 | 0.77 | ESRRG (0.44) | CYP2C19NR1H4ESRRGESRRBMEN1 | |
| SCHEMBL12521072 | 0.77 | TP53 (0.39) | NR1H4ESRRGESRRBKMT2AMAPT | |
| SCHEMBL9958256 | 0.77 | NR1H4 (0.38) | NR1H4ESRRGESRRBMAPTTP53 | |
| SCHEMBL9957773 | 0.77 | NR1H4 (0.38) | NR1H4ESRRGESRRBOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |