Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576265 | 0.80 | HCAR2 (0.42) | BAZ2B | |
| SCHEMBL6079670 | 0.80 | BAZ2B (0.37) | BAZ2BMPOSMN1; SMN2L3MBTL1 | |
| SCHEMBL1233408 | 0.79 | PLA2G10 (0.45) | BAZ2BMPOSMN1; SMN2L3MBTL1 | |
| SCHEMBL9197577 | 0.76 | MMP2 (0.43) | BAZ2BMPOSMN1; SMN2 | |
| SCHEMBL1233249 | 0.75 | MPO (0.49) | MPOSMN1; SMN2 | |
| SCHEMBL22436747 | 0.75 | THRB (0.37) | BAZ2BMPO | |
| SCHEMBL19635566 | 0.72 | MPO (0.40) | BAZ2BMPOSMN1; SMN2 | |
| SCHEMBL6078731 | 0.71 | CLK1 (0.31) | BAZ2BMPO | |
| SCHEMBL13466375 | 0.71 | KDM4C (0.48) | SMN1; SMN2L3MBTL1 | |
| SCHEMBL17324767 | 0.70 | BAZ2B (0.35) | BAZ2BMPOSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710449-B1 | MACROCYCLIC FLUORINE SUBSTITUTED INDOLE DERIVATIVES AS MCL-1 INHIBITORS, FOR USE IN THE TREATMENT OF CANCER | BROAD INST INC (US) | 2022-07-06 | — | — | EP | disclosed |
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |