Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 6/20 | 0.43 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586145 | 0.93 | CNR1 (0.42) | LPAR1LPAR5SLC2A1LPAR2CNR1 | |
| SCHEMBL3586185 | 0.89 | LMNA (0.43) | LPAR1LPAR5SLC2A1MEN1KMT2A | |
| SCHEMBL3571491 | 0.88 | C5AR1 (0.42) | LPAR1LPAR5LPAR2LMNAGAA | |
| SCHEMBL3571746 | 0.86 | SLC2A1 (0.41) | LPAR1LPAR5SLC2A1HTR5AMEN1 | |
| SCHEMBL3586383 | 0.85 | NLRP3 (0.39) | LPAR1LPAR5SLC2A1LPAR2KMT2A | |
| SCHEMBL3571528 | 0.85 | TP53 (0.41) | LPAR1LPAR5LPAR2MEN1KMT2A | |
| SCHEMBL9958121 | 0.85 | LPAR1 (0.43) | LPAR1LPAR5SLC2A1HTR5ALPAR2 | |
| SCHEMBL3579684 | 0.84 | CNR1 (0.40) | LPAR1LPAR5SLC2A1CNR1LMNA | |
| SCHEMBL3569982 | 0.83 | LPAR1 (0.41) | LPAR1LPAR5SLC2A1LPAR2TSHR | |
| SCHEMBL3577812 | 0.82 | LPAR1 (0.43) | LPAR1LPAR5SLC2A1LPAR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |