Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | DPP4 | P27487 | 6/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347472 | 0.81 | NPC1 (0.36) | TSHRTDP1NPC1F10CCR2 | |
| SCHEMBL3584822 | 0.80 | PIK3CA (0.38) | TSHRNPC1F10CCR2PLA2G10 | |
| SCHEMBL4994314 | 0.80 | PLA2G10 (0.45) | SMN1; SMN2F10KDM4ERAB9ACCR2 | |
| SCHEMBL3589089 | 0.78 | NPC1 (0.30) | NPC1 | |
| SCHEMBL3345878 | 0.77 | EGFR (0.37) | SMN1; SMN2TSHRHSD17B10NPC1KDM4E | |
| SCHEMBL3580573 | 0.77 | NPC1 (0.31) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3582637 | 0.74 | NPC1 (0.34) | NPC1CCR2 | |
| SCHEMBL21185866 | 0.66 | KDM4E (0.49) | SMN1; SMN2TSHRHSD17B10TDP1L3MBTL1 | |
| SCHEMBL2799169 | 0.65 | SLC9A1 (0.43) | SMN1; SMN2HSD17B10NPC1F10KDM4E | |
| SCHEMBL3586201 | 0.62 | SLC9A1 (0.38) | SMN1; SMN2HSD17B10NPC1F10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816371-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2010-10-19 | — | — | US | claimed |