Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3589089 | 0.85 | NPC1 (0.30) | NPC1 | |
| SCHEMBL3345878 | 0.79 | EGFR (0.37) | NPC1GAAHPGDSMN1; SMN2LMNA | |
| SCHEMBL3576486 | 0.77 | SMN1; SMN2 (0.36) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3347472 | 0.72 | NPC1 (0.36) | NPC1HPGD | |
| SCHEMBL3584822 | 0.72 | PIK3CA (0.38) | NPC1 | |
| SCHEMBL4994314 | 0.71 | PLA2G10 (0.45) | HPGDRAB9ASMN1; SMN2LMNASRC | |
| SCHEMBL2799169 | 0.67 | SLC9A1 (0.43) | NPC1HPGDRAB9ASMN1; SMN2EGFR | |
| SCHEMBL3582637 | 0.66 | NPC1 (0.34) | NPC1 | |
| SCHEMBL3586201 | 0.64 | SLC9A1 (0.38) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27984706 | 0.64 | POLB (0.47) | HPGDSMN1; SMN2LMNAHTTEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816371-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2010-10-19 | — | — | US | claimed |