Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | F10 | P00742 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347472 | 0.81 | NPC1 (0.36) | NPC1F10TSHRCCR2MAPT | |
| SCHEMBL3576486 | 0.80 | SMN1; SMN2 (0.36) | NPC1F10TSHRCCR2PLA2G10 | |
| SCHEMBL4994314 | 0.80 | PLA2G10 (0.45) | F10CCR2MAPTPLA2G10 | |
| SCHEMBL3345878 | 0.77 | EGFR (0.37) | NPC1TSHRMAPT | |
| SCHEMBL3582637 | 0.74 | NPC1 (0.34) | NPC1CCR2 | |
| SCHEMBL3589089 | 0.72 | NPC1 (0.30) | NPC1 | |
| SCHEMBL3580573 | 0.72 | NPC1 (0.31) | NPC1 | |
| SCHEMBL2799169 | 0.65 | SLC9A1 (0.43) | NPC1F10CCR2MAPTPLA2G10 | |
| SCHEMBL3586201 | 0.62 | SLC9A1 (0.38) | NPC1F10CCR2MAPTPLA2G10 | |
| SCHEMBL396907 | 0.60 | KDM4E (0.56) | PIK3CANPC1TSHRTLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816371-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2010-10-19 | — | — | US | claimed |