Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | CCNC | P24863 | 2/20 | 0.32 |
| ▸ | CDK8 | P49336 | 2/20 | 0.32 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.32 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347472 | 0.77 | NPC1 (0.36) | NPC1CCR2 | |
| SCHEMBL4994314 | 0.76 | PLA2G10 (0.45) | CCR2 | |
| SCHEMBL3584822 | 0.74 | PIK3CA (0.38) | NPC1CCR2 | |
| SCHEMBL3576486 | 0.74 | SMN1; SMN2 (0.36) | NPC1CCR2 | |
| SCHEMBL3345878 | 0.71 | EGFR (0.37) | NPC1 | |
| SCHEMBL3589089 | 0.67 | NPC1 (0.30) | NPC1 | |
| SCHEMBL3580573 | 0.66 | NPC1 (0.31) | NPC1 | |
| SCHEMBL2799169 | 0.60 | SLC9A1 (0.43) | NPC1CCR2 | |
| SCHEMBL3582640 | 0.59 | PARP1 (0.53) | — | |
| SCHEMBL5746207 | 0.58 | KDM4E (0.44) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816371-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2010-10-19 | — | — | US | claimed |