Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5176812 | 0.83 | P2RX7 (0.57) | P2RX7EPHX2NR1H4 | |
| SCHEMBL3580855 | 0.78 | P2RX7 (0.46) | P2RX7LMNAPOLBEPHX2NR1H4 | |
| SCHEMBL2133620 | 0.78 | LMNA (0.52) | LMNAALDH1A1EPHX2NR1H4 | |
| SCHEMBL3202382 | 0.78 | LMNA (0.53) | LMNA | |
| SCHEMBL3235987 | 0.76 | BACE1 (0.60) | LMNAALDH1A1 | |
| SCHEMBL5175983 | 0.76 | — | — | |
| SCHEMBL3576790 | 0.75 | CA1 (0.47) | LMNAEPHX2NR1H4 | |
| SCHEMBL3245317 | 0.75 | BACE1 (0.52) | LMNA | |
| SCHEMBL5177106 | 0.74 | LMNA (0.51) | LMNAPOLBEPHX2NR1H4 | |
| SCHEMBL3273904 | 0.74 | LMNA (0.70) | LMNAALDH1A1EPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |