Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 13/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 13/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | CCR9 | P51686 | 2/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3575555 | 0.93 | F10 (0.42) | HCRTR1HCRTR2CCR9SERPINE1F10 | |
| SCHEMBL3581366 | 0.90 | HCRTR1 (0.38) | HCRTR1HCRTR2TRPM8CCR9SERPINE1 | |
| SCHEMBL1397562 | 0.85 | HCRTR1 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL3581537 | 0.85 | PTGER2 (0.42) | HCRTR1HCRTR2CCR9 | |
| SCHEMBL3584396 | 0.84 | C5AR1 (0.44) | CCR9SERPINE1F10KLKB1 | |
| SCHEMBL3575609 | 0.84 | LMNA (0.43) | SERPINE1 | |
| SCHEMBL3580698 | 0.83 | C5AR1 (0.44) | CCR9 | |
| SCHEMBL1397703 | 0.83 | HCRTR1 (0.37) | HCRTR1HCRTR2CCR9SERPINE1F10 | |
| SCHEMBL3581193 | 0.82 | CCR9 (0.39) | CCR9SERPINE1F10KLKB1 | |
| SCHEMBL3583634 | 0.81 | SERPINE1 (0.39) | CCR9SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |