Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | CCR9 | P51686 | 2/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ESRRG | P62508 | 3/20 | 0.37 |
| ▸ | ESRRB | O95718 | 1/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579634 | 0.92 | SERPINE1 (0.40) | SERPINE1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3570707 | 0.91 | C5AR1 (0.39) | KDM4EALDH1A1GLAGAANR1H4 | |
| SCHEMBL3584396 | 0.90 | C5AR1 (0.44) | SERPINE1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3575609 | 0.86 | LMNA (0.43) | SERPINE1LMNASMN1; SMN2C5AR1MEN1 | |
| SCHEMBL3581193 | 0.86 | CCR9 (0.39) | SERPINE1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3580741 | 0.86 | C5AR1 (0.40) | SERPINE1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3569982 | 0.83 | LPAR1 (0.41) | SERPINE1ALDH1A1GAANR1H4CCR9 | |
| SCHEMBL3580698 | 0.83 | C5AR1 (0.44) | KDM4EALDH1A1GLAGAACCR9 | |
| SCHEMBL3578799 | 0.83 | TP53 (0.39) | NR1H4ESRRGESRRBC5AR1TP53 | |
| SCHEMBL3577656 | 0.83 | CNR1 (0.42) | SERPINE1KDM4EALDH1A1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |