SCHEMBL357717

SCHEMBL357717

Cc1c(C)c(C)c(CO)c(C)c1C

nearest known ligand 0.32

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
HSD17B10 Q99714 1/20 0.32
GABRA1 P14867 1/20 0.32
GABRG2 P18507 1/20 0.32
GABRB3 P28472 1/20 0.32
CA2 P00918 1/20 0.31
CA4 P22748 1/20 0.31
DRD4 P21917 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL217886 0.96 KDM4E (0.31) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL217789 0.96 KDM4E (0.33) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL10598219 0.92 KDM4E (0.32) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL4175469 0.88 KDM4E (0.33) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL13199170 0.85 KDM4E (0.32) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL5516684 0.83 KDM4E (0.38) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL13025134 0.81 KDM4E (0.37) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL12766214 0.80 KDM4E (0.33) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL19253093 0.78
SCHEMBL8351615 0.78 KDM4E (0.35) KDM4EALDH1A1HPGDHSD17B10GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102762532-B The manufacture method of cyano group alkenyl cyclopropanecarboxylic acid salt SUMITOMO CHEMICAL CO.,LTD. (JP) 2015-07-29 CN disclosed
EP-1792889-B1 Process for the preparation of carboxylic acid esters SUMITOMO CHEMICAL CO (JP) 2015-03-04 EP disclosed
CN-102365264-B Process for producing 3-(2-cyano-1-propenyl)-2,2- dimethylcyclopropanecarboxylic acid or salt thereof SUMITOMO CHEMICAL CO 2014-05-21 CN disclosed
EP-2418197-B1 PROCESS FOR PRODUCING 3-(2-CYANO-1-PROPENYL)-2,2- DIMETHYLCYCLOPROPANECARBOXYLIC ACID OR SALT THEREOF SUMITOMO CHEMICAL CO (JP) 2014-05-07 EP disclosed
EP-1547995-B1 Process for the preparation of carboxylic acid esters SUMITOMO CHEMICAL CO (JP) 2014-05-07 EP disclosed
EP-1758859-B1 GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES LILLY CO ELI (US) 2013-07-17 EP disclosed
US-8461370-B2 Process for producing 3-(2-cyano-1-propenyl)-2,2- dimethylcyclopropanecarboxylic acid or salt thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-06-11 US disclosed
EP-2537828-A1 METHOD FOR PRODUCING CYANOALKENYLCYCLOPROPANECARBOXYLIC ACID SALT Sumitomo Chemical Company, Limited (JP) 2012-12-26 EP disclosed
US-20120310003-A1 METHOD FOR PRODUCING CYANOALKENYLCYCLOPROPANECARBOXYLIC ACID SALT SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-12-06 US disclosed
CN-102762532-A Method for producing cyanoalkenylcyclopropanecarboxylic acid salt SUMITOMO CHEMICAL CO 2012-10-31 CN disclosed
CN-1369476-A Process for prepn. of cyclopropane formic ether SUMITOMO CHEMICAL CO (JP) 2002-09-18 CN disclosed
US-6441220-B1 ESTERIFICATION WITH ALCOHOL IN PRESENCE OF BASIC CATALYSTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-08-27 US disclosed
EP-1227077-A2 Process for producing cyclopropanecarboxylates Sumitomo Chemical Co.,Ltd. (JP) 2002-07-31 EP disclosed
CN-1354166-A Process for preparing cyclopropane carboxylic acid ester SUMITOMO CHEMICAL CO (JP) 2002-06-19 CN disclosed
EP-1203760-A1 Method for producing cyclopropanecarboxylates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-05-08 EP disclosed
US-20020052525-A1 Method for producing cyclopropanecarboxylates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-05-02 US disclosed
CN-1282729-A Preparation method of cyclopropane carboxylic acid ester SUMITOMO CHEMICAL CO (JP) 2001-02-07 CN disclosed
EP-1061065-A2 Methods for producing cyclopropane carboxylates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-12-20 EP disclosed
CN-1255489-A Method for preparing cyclopropane carboxylic ester SUMITOMO CHEM ENG (JP) 2000-06-07 CN disclosed
EP-0992479-A1 Method for producing cyclopropanecarboxylates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-04-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120310003-A1 METHOD FOR PRODUCING CYANOALKENYLCYCLOPROPANECARBOXYLIC ACID SALT MCCC2, AOC2, DDC KDM4E 3274/4885ALDH1A1 809/4885HPGD 2540/4885
US-20020052525-A1 Method for producing cyclopropanecarboxylates CYP8B1, SRD5A2, CYP21A2 KDM4E 641/4885ALDH1A1 671/4885HPGD 1419/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.