SCHEMBL4175469

SCHEMBL4175469

Cc1c(CO)c(C)c(CO)c(C)c1CO

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
HSD17B10 Q99714 1/20 0.33
GABRA1 P14867 1/20 0.33
GABRG2 P18507 1/20 0.33
GABRB3 P28472 1/20 0.33
CA2 P00918 1/20 0.32
CA4 P22748 1/20 0.32
DRD4 P21917 1/20 0.32
PGK1 P00558 1/20 0.31
PGK2 P07205 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL217886 0.93 KDM4E (0.31) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL12766214 0.92 KDM4E (0.33) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL217789 0.92 KDM4E (0.33) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL12766210 0.88 KDM4E (0.32) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL357717 0.88 KDM4E (0.32) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL2798558 0.87 KDM4E (0.38) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL5596447 0.84
SCHEMBL8351615 0.82 KDM4E (0.35) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL10598219 0.80 KDM4E (0.32) KDM4EALDH1A1HPGDHSD17B10GABRA1
SCHEMBL13199170 0.80 KDM4E (0.32) KDM4EALDH1A1HPGDHSD17B10GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230312457-A1 LOW-MIGRATION HINDERED PHENOL ANTIOXIDANT COMPOUND, PREPARATION METHOD AND COMPOSITION TSENG, JERRY (TW) 2023-10-05 US disclosed
US-7910664-B2 3 to 6 Polyalkylene oxide, polyacrylate, a polylactone, polylactam or derivative side-branches connected to a benzene central molecule by a methylene group, especially initiated by hexakis(bromomethyl)benzene; films for electronic devices; nucleophilic substitution; benzene ring formation; ATRP LG CHEM, LTD. (KR) 2011-03-22 US disclosed
US-20090238768-A1 MULTIMERIC MAGNETIC RESONANCE CONTRAST AGENTS AXELSSON OSKAR 2009-09-24 US disclosed
US-20090238768-A1 MULTIMERIC MAGNETIC RESONANCE CONTRAST AGENTS AXELSSON OSKAR 2009-09-24 US disclosed
US-20090238768-A1 MULTIMERIC MAGNETIC RESONANCE CONTRAST AGENTS AXELSSON OSKAR 2009-09-24 US disclosed
US-20080161523-A1 Radially multi-branched polymer and porous film using the same CHEONG JAE HO 2008-07-03 US disclosed
US-7297722-B2 Radially multi-branched polymer and porous film using the same LG CHEM, LTD. (KR) 2007-11-20 US disclosed
WO-2007064227-A1 MULTIMERIC MAGENTIC RESONANCE CONTRAST AGENTS GE HEALTHCARE AS (NO) 2007-06-07 WO disclosed
US-7208140-B2 Trimeric macrocyclic substituted benzene derivatives SCHERING AKTIENGESELLSCHAFT (DE) 2007-04-24 US disclosed
US-5795581-A Controlled release of molecular components of dendrimer/bioactive complexes SANDIA CORPORATION (US) 1998-08-18 US disclosed
WO-1996030002-A1 CONTROLLED RELEASE OF MOLECULAR COMPONENTS COMPRISING THE USE OF FRAGMENTING AND EXPANDING MOLECULES SANDIA CORPORATION (US) 1996-10-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080161523-A1 Radially multi-branched polymer and porous film using the same PUF60, PARG, PARN KDM4E 589/4885ALDH1A1 3356/4885HPGD 3825/4885
US-20090238768-A1 MULTIMERIC MAGNETIC RESONANCE CONTRAST AGENTS MAG, MSR1, FABP7 KDM4E 4443/4885ALDH1A1 2448/4885HPGD 481/4885
US-20230312457-A1 LOW-MIGRATION HINDERED PHENOL ANTIOXIDANT COMPOUND, PREPARATION METHOD AND COMPOSITION COMT, CAT, GPX4 KDM4E 2420/4885ALDH1A1 921/4885HPGD 159/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.