Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 4/20 | 0.38 |
| ▸ | PPARA | Q07869 | 4/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.37 |
| ▸ | LPAR5 | Q9H1C0 | 5/20 | 0.37 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.36 |
| ▸ | SLC2A8 | Q9NY64 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | MTTP | P55157 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576589 | 0.94 | CHRNA7 (0.40) | SLC2A1CHRNA7PPARGPPARAPPARD | |
| SCHEMBL3575233 | 0.87 | SLC2A1 (0.42) | SLC2A1PPARGPPARAPPARDLPAR1 | |
| SCHEMBL3583406 | 0.87 | CNR1 (0.41) | SLC2A1PTGER4LPAR1LPAR5 | |
| SCHEMBL3579477 | 0.86 | MCHR1 (0.37) | NLRP3SLC2A1CHRNA7PTGER4PTGER2 | |
| SCHEMBL3574217 | 0.85 | MCHR1 (0.37) | NLRP3SLC2A1CHRNA7PTGER4PTGER2 | |
| SCHEMBL3577563 | 0.85 | NLRP3 (0.42) | NLRP3SLC2A1PPARGPPARAPPARD | |
| SCHEMBL3569329 | 0.80 | C5AR1 (0.41) | CHRNA7C5AR1 | |
| SCHEMBL3581889 | 0.79 | C5AR1 (0.40) | CHRNA7C5AR1 | |
| SCHEMBL3577662 | 0.79 | LPAR1 (0.43) | PPARGPPARAPPARDLPAR1LPAR5 | |
| SCHEMBL3577569 | 0.79 | C5AR1 (0.42) | CHRNA7PTGER4LPAR1LPAR5C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |