Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 6/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 3/20 | 0.36 |
| ▸ | PPARA | Q07869 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | FABP2 | P12104 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PTGIR | P43119 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577424 | 0.94 | NLRP3 (0.39) | CHRNA7C5AR1LPAR1LPAR5PPARD | |
| SCHEMBL3575233 | 0.87 | SLC2A1 (0.42) | LPAR1LPAR5PPARDPPARAPPARG | |
| SCHEMBL3583406 | 0.87 | CNR1 (0.41) | LPAR1LPAR5MEN1KMT2ASLC2A1 | |
| SCHEMBL3577569 | 0.85 | C5AR1 (0.42) | CHRNA7C5AR1LPAR1LPAR5SMN1; SMN2 | |
| SCHEMBL3577662 | 0.85 | LPAR1 (0.43) | C5AR1LPAR1LPAR5LPAR2PPARD | |
| SCHEMBL3569329 | 0.84 | C5AR1 (0.41) | CHRNA7C5AR1MEN1KMT2AF10 | |
| SCHEMBL3581889 | 0.83 | C5AR1 (0.40) | CHRNA7C5AR1MEN1KMT2AF10 | |
| SCHEMBL3583638 | 0.82 | C5AR1 (0.41) | CHRNA7C5AR1MEN1KMT2AMAPT | |
| SCHEMBL3577563 | 0.80 | NLRP3 (0.42) | C5AR1LPAR1LPAR5LPAR2PPARD | |
| SCHEMBL3576692 | 0.80 | ESRRG (0.37) | C5AR1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |