Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | HSPH1 | Q92598 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577493 | 0.90 | LMNA (0.40) | LMNAHPGDCNR1MPOHSPH1 | |
| SCHEMBL3584132 | 0.87 | LMNA (0.39) | LMNAHPGDCNR1MPOS1PR1 | |
| SCHEMBL3583457 | 0.87 | LMNA (0.39) | LMNAHPGDCNR1MPOHSPH1 | |
| SCHEMBL3577580 | 0.86 | LMNA (0.38) | LMNAHPGDCNR1MPOHSPH1 | |
| SCHEMBL3576637 | 0.84 | LMNA (0.41) | LMNAHPGDCNR1MPOSCN9A | |
| SCHEMBL9957466 | 0.84 | RORC (0.35) | LMNAHPGDCNR1RORCS1PR1 | |
| SCHEMBL3576623 | 0.82 | LMNA (0.41) | LMNAHPGDCNR1MPOHSPH1 | |
| SCHEMBL3577795 | 0.82 | LMNA (0.38) | LMNAHPGDCNR1MPOHSPH1 | |
| SCHEMBL3577153 | 0.81 | LMNA (0.42) | LMNAHPGDCNR1MPOSCN9A | |
| SCHEMBL3574585 | 0.80 | LMNA (0.42) | LMNAHPGDCNR1S1PR1GRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |