Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.34 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | PRKX | P51817 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9957248 | 0.86 | KCNH2 (0.38) | GRM2GRM3KCNH2CHIT1CHIA | |
| SCHEMBL3577957 | 0.84 | LMNA (0.37) | RORCS1PR1S1PR5GRK5CDK8 | |
| SCHEMBL3574585 | 0.82 | LMNA (0.42) | GRM2GRM3KCNH2CHIT1CHIA | |
| SCHEMBL3576111 | 0.79 | LMNA (0.41) | GRM2GRM3KCNH2CHIT1CHIA | |
| SCHEMBL3576637 | 0.75 | LMNA (0.41) | S1PR1S1PR5LMNAHPGDCNR1 | |
| SCHEMBL3583120 | 0.75 | GRM2 (0.37) | GRM2GRM3KCNH2CHIT1CHIA | |
| SCHEMBL3577493 | 0.73 | LMNA (0.40) | S1PR1S1PR5GRK5CDK8LMNA | |
| SCHEMBL3576623 | 0.73 | LMNA (0.41) | S1PR1S1PR5GRK5CDK8TRPV1 | |
| SCHEMBL3577153 | 0.71 | LMNA (0.42) | S1PR1S1PR5GRK5CDK8LMNA | |
| SCHEMBL3586134 | 0.71 | SLC2A1 (0.36) | S1PR1S1PR5GRK5CDK8TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |