Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3569921 | 0.89 | SERPINE1 (0.47) | SERPINE1KDM4EHSD17B10PPARGNR1H4 | |
| SCHEMBL3575564 | 0.85 | SERPINE1 (0.43) | SERPINE1KDM4EHSD17B10PPARGNR1H4 | |
| SCHEMBL3569048 | 0.84 | SERPINE1 (0.42) | SERPINE1KDM4EHSD17B10PPARGNR1H4 | |
| SCHEMBL3569791 | 0.84 | LPAR1 (0.43) | SERPINE1KDM4EHSD17B10NR1H4SMN1; SMN2 | |
| SCHEMBL3578904 | 0.82 | LMNA (0.44) | SERPINE1KDM4EHSD17B10HDAC1HDAC6 | |
| SCHEMBL3581404 | 0.79 | CNR1 (0.43) | SERPINE1KDM4EHSD17B10PPARGNR1H4 | |
| SCHEMBL3581531 | 0.79 | C5AR1 (0.43) | HSP90AA1SERPINE1KDM4EF10LMNA | |
| SCHEMBL3584396 | 0.78 | C5AR1 (0.44) | SERPINE1KDM4EF10LMNAHTT | |
| SCHEMBL3576379 | 0.77 | HSP90AA1 (0.46) | HSP90AA1HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL3581435 | 0.76 | TP53 (0.41) | HSP90AA1SERPINE1SOAT1F10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |