Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20970479 | 0.88 | ALDH1A1 (0.50) | ALDH1A1MAPK1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL10178021 | 0.85 | ALDH1A1 (0.48) | ALDH1A1MAPK1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL2065858 | 0.85 | ALDH1A1 (0.48) | ALDH1A1MAPK1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL1665674 | 0.85 | ALDH1A1 (0.48) | ALDH1A1MAPK1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL14154117 | 0.84 | ALDH1A1 (0.53) | ALDH1A1MAPK1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL22897654 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MAPK1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL15483808 | 0.81 | MAPT (0.45) | ALDH1A1MAPK1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL16285728 | 0.81 | AKR1C3 (0.50) | ALDH1A1MAPK1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL14947932 | 0.81 | MEN1 (0.48) | ALDH1A1MAPK1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL14791578 | 0.81 | SMN1; SMN2 (0.49) | ALDH1A1MAPK1SMN1; SMN2MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614215-B2 | Quinoxaline inhibitors of phosphoinositide-3-kinases (PI3Ks) | MERCK SERONO SA (CH) | 2013-12-24 | — | — | US | disclosed |
| US-20100137308-A1 | Quinoxaline Compounds and Use Thereof | MERCK SERONO SA (CH) | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137308-A1 | Quinoxaline Compounds and Use Thereof | PFKP, PDXK, PF4 | ALDH1A1 577/4885MAPK1 2681/4885SMN1; SMN2 3366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.