Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 3/20 | 0.38 |
| ▸ | ESRRB | O95718 | 2/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | LIPC | P11150 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3578664 | 0.87 | CYP2C19 (0.39) | NR1H4ESRRGESRRBNR1I3MEN1 | |
| SCHEMBL3580658 | 0.85 | RAF1 (0.39) | NR1H4ESRRGESRRBMEN1KMT2A | |
| SCHEMBL3580374 | 0.84 | ESRRG (0.36) | NR1H4ESRRGESRRBNR1I3SIGMAR1 | |
| SCHEMBL3576692 | 0.83 | ESRRG (0.37) | NR1H4ESRRGESRRBNR1I3SIGMAR1 | |
| SCHEMBL3574285 | 0.82 | ESRRG (0.36) | NR1H4ESRRGESRRBNR1I3SIGMAR1 | |
| SCHEMBL3587153 | 0.82 | ESRRG (0.36) | NR1H4ESRRGESRRBNR1I3SIGMAR1 | |
| SCHEMBL3584126 | 0.82 | ESRRG (0.36) | NR1H4ESRRGESRRBNR1I3SIGMAR1 | |
| SCHEMBL3575452 | 0.81 | KMT2A (0.42) | NR1H4ESRRGESRRBMEN1KMT2A | |
| SCHEMBL3580346 | 0.80 | ESRRG (0.35) | NR1H4ESRRGESRRBNR1I3SIGMAR1 | |
| SCHEMBL3574429 | 0.80 | KDM4C (0.39) | NR1H4ESRRGESRRBSIGMAR1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |