Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | ESRRG | P62508 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | ESRRB | O95718 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CENPE | Q02224 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581265 | 0.90 | NR1H4 (0.39) | NR1H4ESRRGHSP90AA1ESRRBOPRM1 | |
| SCHEMBL3584126 | 0.89 | ESRRG (0.36) | NR1H4ESRRGGBA1HSP90AA1ESRRB | |
| SCHEMBL9958256 | 0.89 | NR1H4 (0.38) | NR1H4ESRRGESRRBOPRM1OPRD1 | |
| SCHEMBL3575573 | 0.87 | HSP90AA1 (0.36) | NR1H4ESRRGGBA1HSP90AA1ESRRB | |
| SCHEMBL9957841 | 0.81 | ESRRG (0.39) | NR1H4ESRRGHSP90AA1ESRRBOPRM1 | |
| SCHEMBL3573203 | 0.80 | RAF1 (0.40) | NR1H4ESRRGESRRBOPRM1OPRD1 | |
| SCHEMBL3576126 | 0.80 | CYP2C19 (0.37) | NR1H4ESRRGHSP90AA1ESRRBOPRM1 | |
| SCHEMBL3584062 | 0.79 | GBA1 (0.34) | GBA1HSP90AA1OPRM1OPRD1CENPE | |
| SCHEMBL3574044 | 0.79 | NR1H4 (0.37) | NR1H4ESRRGHSP90AA1ESRRBOPRM1 | |
| SCHEMBL3576692 | 0.79 | ESRRG (0.37) | NR1H4ESRRGHSP90AA1ESRRBOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984322-B1 | BENZAMIDE AND HETEROARENE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-09-26 | — | — | EP | claimed |
| EP-1984322-B1 | BENZAMIDE AND HETEROARENE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-09-26 | — | — | EP | disclosed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |