Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4958142 | 0.95 | NPSR1 (0.42) | NPSR1TSHRRXFP1HDAC3HDAC4 | |
| SCHEMBL1674865 | 0.81 | NPSR1 (0.41) | NPSR1TSHRRXFP1HDAC3HDAC4 | |
| SCHEMBL3919726 | 0.78 | SLC9A1 (0.38) | NPSR1TSHRSLC9A1POLBMAPK1 | |
| SCHEMBL6668090 | 0.77 | SMN1; SMN2 (0.40) | NPSR1TSHRRXFP1HDAC3HDAC4 | |
| SCHEMBL4958663 | 0.76 | FAAH (0.35) | — | |
| SCHEMBL2107219 | 0.74 | NPSR1 (0.45) | NPSR1TSHRRXFP1HDAC3HDAC4 | |
| SCHEMBL30269029 | 0.74 | TSHR (0.45) | NPSR1TSHRRXFP1HDAC3HDAC4 | |
| SCHEMBL44479 | 0.73 | SLC9A1 (0.41) | NPSR1TSHRSLC9A1POLBMAPK1 | |
| SCHEMBL2824611 | 0.73 | SLC9A1 (0.41) | NPSR1TSHRSLC9A1POLBMAPK1 | |
| SCHEMBL1941412 | 0.73 | SLC9A1 (0.41) | NPSR1TSHRSLC9A1POLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075986-A1 | Oxophenyl-Cyclohexyl-Propanolamine Derivatives, Production And Use Thereof In Therapeutics | SANOFI-AVENTIS (FR) | 2010-03-25 | — | — | US | disclosed |
| US-7625929-B2 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use thereof in therapeutics | SANOFI-AVENTIS (FR) | 2009-12-01 | — | — | US | disclosed |
| US-7453010-B2 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | SANOFI AVENTIS (FR) | 2008-11-18 | — | — | US | disclosed |
| US-20060100283-A1 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | SANOFI-AVENTIS (FR) | 2006-05-11 | — | — | US | disclosed |
| US-20050176731-A1 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use therof in therapeutics | SANOFI-AVENTIS (FR) | 2005-08-11 | — | — | US | disclosed |
| EP-1453860-A2 | NOVEL GLUCOSE-DEPENDANT INSULINS | NOVO NORDISK A/S (DK) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003048195-A2 | GLUCOSE DEPENDANT RELEASE OF INSULIN FROM GLUCOSE SENSING INSULIN DERIVATIVES | NOVO NORDISK A/S (DK) | 2003-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100283-A1 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | CHRM1, CHRM2, C1R | NPSR1 64/4885TSHR 177/4885RXFP1 326/4885 |
| US-20100075986-A1 | Oxophenyl-Cyclohexyl-Propanolamine Derivatives, Production And Use Thereof In Therapeutics | HRH4, HRH3, AOC3 | NPSR1 96/4885TSHR 317/4885RXFP1 1746/4885 |
| US-20050176731-A1 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use therof in therapeutics | HRH4, HRH3, HTR3C | NPSR1 64/4885TSHR 317/4885RXFP1 618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.