Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 6/20 | 0.45 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3574025 | 0.92 | C5AR1 (0.46) | LPAR1LPAR5LPAR2SMN1; SMN2TP53 | |
| SCHEMBL3584423 | 0.86 | LPAR1 (0.43) | LPAR1LPAR5LPAR2SMN1; SMN2TP53 | |
| SCHEMBL3569791 | 0.85 | LPAR1 (0.43) | LPAR1LPAR5TSHRLPAR2SMN1; SMN2 | |
| SCHEMBL3589450 | 0.83 | RECQL (0.44) | LPAR1LPAR5LPAR2SMN1; SMN2TP53 | |
| SCHEMBL3587845 | 0.83 | LPAR1 (0.42) | LPAR1LPAR5LPAR2CA12CA1 | |
| SCHEMBL3576810 | 0.82 | LMNA (0.42) | LPAR1LPAR5SMN1; SMN2C5AR1KDM4E | |
| SCHEMBL3584396 | 0.78 | C5AR1 (0.44) | LPAR1LPAR5SMN1; SMN2C5AR1KDM4E | |
| SCHEMBL3573515 | 0.77 | C5AR1 (0.46) | LPAR1LPAR5LPAR2TP53CA12 | |
| SCHEMBL3581531 | 0.76 | C5AR1 (0.43) | LPAR1LPAR5SMN1; SMN2C5AR1KDM4E | |
| SCHEMBL3569921 | 0.76 | SERPINE1 (0.47) | SMN1; SMN2C5AR1KDM4EHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |