Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.37 |
| ▸ | RORB | Q92753 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.37 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3574025 | 0.89 | C5AR1 (0.46) | RECQLC5AR1KDM4ETP53MAPT | |
| SCHEMBL3584423 | 0.87 | LPAR1 (0.43) | RECQLC5AR1KDM4ETP53MAPT | |
| SCHEMBL3569048 | 0.86 | SERPINE1 (0.42) | C5AR1KDM4EMAPTFLT1FLT4 | |
| SCHEMBL3581208 | 0.83 | LPAR1 (0.45) | C5AR1KDM4ETP53LPAR1LPAR2 | |
| SCHEMBL3576810 | 0.83 | LMNA (0.42) | C5AR1KDM4ELPAR1LPAR5LMNA | |
| SCHEMBL3587845 | 0.80 | LPAR1 (0.42) | C5AR1LPAR1LPAR2LPAR5 | |
| SCHEMBL12521286 | 0.74 | LMNA (0.51) | C5AR1LPAR1LPAR5LMNASMN1; SMN2 | |
| SCHEMBL3584396 | 0.74 | C5AR1 (0.44) | C5AR1KDM4EFLT1FLT4KDR | |
| SCHEMBL3573515 | 0.74 | C5AR1 (0.46) | RECQLC5AR1KDM4ETP53MAPT | |
| SCHEMBL3579634 | 0.73 | SERPINE1 (0.40) | C5AR1KDM4ETP53MAPTFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |