Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.62 |
| ▸ | DRD3 | P35462 | 3/20 | 0.62 |
| ▸ | HTR1A | P08908 | 8/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581468 | 0.88 | PARP1 (0.62) | DRD2DRD3HTR1APARP1 | |
| SCHEMBL6581372 | 0.80 | DRD2 (0.59) | DRD2DRD3HTR1AHTR7SLC6A2 | |
| SCHEMBL3575207 | 0.79 | DYRK3 (0.53) | CHEK2PARP1 | |
| SCHEMBL3580302 | 0.78 | DYRK3 (0.54) | CHEK2PARP1 | |
| SCHEMBL9006384 | 0.77 | DRD3 (1.00) | DRD2DRD3SLC6A2SLC6A4HRH2 | |
| SCHEMBL3582864 | 0.76 | GRK6 (0.48) | HTR1AHTR7SLC6A4CHEK2PARP1 | |
| SCHEMBL3574441 | 0.75 | AURKA (0.75) | DRD2DRD3HTR1ACHEK2PARP1 | |
| SCHEMBL3577822 | 0.75 | MAP4K4 (0.72) | CHEK2PARP1 | |
| SCHEMBL3578582 | 0.75 | CHEK2 (0.56) | CHEK2PARP1 | |
| SCHEMBL3577456 | 0.73 | MAP4K4 (0.59) | CHEK2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |