Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 7/20 | 0.46 |
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 4/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 2/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580358 | 0.89 | PARP1 (0.53) | JAK2CHEK2PARP1 | |
| SCHEMBL3582373 | 0.85 | PARP1 (0.49) | CHEK2PARP1 | |
| SCHEMBL3584976 | 0.83 | ACVR1 (0.42) | HTR7HTR1AJAK2CHEK2PARP1 | |
| SCHEMBL3582857 | 0.83 | PARP1 (0.66) | CHEK2PARP1 | |
| SCHEMBL6805728 | 0.81 | AURKA (0.53) | JAK2PARP1 | |
| SCHEMBL3585144 | 0.80 | PARP1 (0.64) | PARP1TP53HTT | |
| SCHEMBL5621810 | 0.79 | HTR3A (0.52) | PARP1HTR3A | |
| SCHEMBL6812407 | 0.78 | AURKA (0.50) | JAK2PARP1 | |
| SCHEMBL3579908 | 0.77 | PARP1 (0.61) | CHEK2PARP1 | |
| SCHEMBL3587289 | 0.77 | AURKA (0.56) | JAK2CHEK2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |