Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 9/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 6/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | CCR9 | P51686 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27730491 | 0.96 | LPAR1 (0.40) | NLRP3LPAR1LPAR5LPAR2C5AR1 | |
| SCHEMBL27750952 | 0.89 | NLRP3 (0.40) | NLRP3LPAR1LPAR2SLC2A1 | |
| SCHEMBL3577892 | 0.88 | SLC2A1 (0.40) | LPAR1LPAR5LPAR2SLC2A1C5AR1 | |
| SCHEMBL3581908 | 0.84 | NLRP3 (0.41) | NLRP3LPAR1LPAR5LPAR2SLC2A1 | |
| SCHEMBL3569645 | 0.82 | CCR9 (0.43) | NLRP3LPAR1LPAR5LPAR2SLC2A1 | |
| SCHEMBL27750937 | 0.82 | C5AR1 (0.40) | NLRP3LPAR1LPAR5LPAR2C5AR1 | |
| SCHEMBL3576630 | 0.82 | LPAR1 (0.37) | LPAR1LPAR5LPAR2C5AR1 | |
| SCHEMBL3576208 | 0.81 | NLRP3 (0.42) | NLRP3LPAR1LPAR5LPAR2SLC2A1 | |
| SCHEMBL3576381 | 0.81 | STAT3 (0.38) | LPAR1LPAR5LPAR2 | |
| SCHEMBL3581285 | 0.80 | LPAR1 (0.36) | LPAR1LPAR5LPAR2C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |