Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7455876 | 0.85 | F2 (0.47) | F2FPR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7407782 | 0.83 | F2 (0.46) | F2FPR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3588460 | 0.81 | SMN1; SMN2 (0.38) | F2FPR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3582673 | 0.77 | SMN1; SMN2 (0.46) | F2SMN1; SMN2KDM4EALDH1A1POLB | |
| SCHEMBL8498289 | 0.73 | HDAC6 (0.40) | F2FPR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL31006001 | 0.71 | KDM4E (0.37) | FPR2SMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL19468957 | 0.70 | KDM4E (0.43) | F2FPR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL29427431 | 0.70 | POLB (0.50) | F2FPR2KDM4EALDH1A1POLB | |
| SCHEMBL15335292 | 0.68 | ALPL (0.47) | FPR2SMN1; SMN2KDM4EALDH1A1POLB | |
| SCHEMBL3577086 | 0.68 | ALDH1A1 (0.41) | F2SMN1; SMN2KDM4EALDH1A1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | MERCK SHARP & DOHME CORP. | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | CXCR3, CXCR1, CXCR2 | F2 2697/4885FPR2 64/4885SMN1; SMN2 4711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.