Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8498289 | 0.87 | HDAC6 (0.40) | SMN1; SMN2F2FPR2KDM4EALDH1A1 | |
| SCHEMBL13031346 | 0.83 | CSNK2A2 (0.41) | SMN1; SMN2KDM4EALDH1A1POLBHDAC6 | |
| SCHEMBL3582137 | 0.81 | F2 (0.47) | SMN1; SMN2F2FPR2KDM4EALDH1A1 | |
| SCHEMBL3584041 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM4EALDH1A1POLBKMT2A | |
| SCHEMBL3588862 | 0.73 | ENPP2 (0.36) | SMN1; SMN2FPR2KDM4EALDH1A1POLB | |
| SCHEMBL31006001 | 0.71 | KDM4E (0.37) | SMN1; SMN2FPR2KDM4EALDH1A1KMT2A | |
| SCHEMBL23410471 | 0.70 | KDM4E (0.41) | SMN1; SMN2F2FPR2KDM4EALDH1A1 | |
| SCHEMBL7455876 | 0.70 | F2 (0.47) | SMN1; SMN2F2FPR2KDM4EALDH1A1 | |
| SCHEMBL19468957 | 0.70 | KDM4E (0.43) | SMN1; SMN2F2FPR2KDM4EALDH1A1 | |
| SCHEMBL29427431 | 0.70 | POLB (0.50) | F2FPR2KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | MERCK SHARP & DOHME CORP. | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | CXCR3, CXCR1, CXCR2 | SMN1; SMN2 4711/4885F2 2697/4885FPR2 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.