Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.64 |
| ▸ | HRH2 | P25021 | 6/20 | 0.54 |
| ▸ | HRH1 | P35367 | 6/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | LTA4H | P09960 | 2/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21814266 | 0.84 | SIGMAR1 (0.62) | HRH3HRH2HRH1SIGMAR1 | |
| SCHEMBL3570133 | 0.80 | ALDH1A1 (0.64) | HRH3HRH2HRH1SIGMAR1LTA4H | |
| SCHEMBL4473444 | 0.79 | HRH3 (0.73) | HRH3HRH2HRH1 | |
| SCHEMBL21814280 | 0.79 | HRH3 (0.73) | HRH3HRH2HRH1 | |
| SCHEMBL28386934 | 0.79 | LTA4H (0.57) | HRH3HRH2HRH1LTA4H | |
| SCHEMBL23963302 | 0.79 | LTA4H (0.57) | HRH3HRH2HRH1LTA4H | |
| SCHEMBL23963274 | 0.79 | LTA4H (0.57) | HRH3HRH2HRH1LTA4H | |
| SCHEMBL8224693 | 0.79 | HRH3 (0.54) | HRH3HRH2HRH1 | |
| SCHEMBL14618951 | 0.78 | HRH3 (0.67) | HRH3HRH2HRH1SIGMAR1LTA4H | |
| SCHEMBL4457910 | 0.78 | LTA4H (0.76) | HRH3HRH1LTA4HPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7749530-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2010-07-06 | — | — | US | disclosed |
| WO-2010075197-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2010-07-01 | — | — | WO | disclosed |
| US-7692005-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-20090208557-A1 | Kinase inhibitors | ALLERGAN, INC. | 2009-08-20 | — | — | US | disclosed |
| EP-1902025-A1 | KINASE INHIBITORS | Allergan, Inc. (US) | 2008-03-26 | — | — | EP | disclosed |
| US-20070032478-A1 | Kinase Inhibitors | ALLERGAN, INC. | 2007-02-08 | — | — | US | disclosed |
| WO-2007008895-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090208557-A1 | Kinase inhibitors | PTK2, MAP3K6, MAP3K20 | HRH3 2899/4885HRH2 3115/4885HRH1 3237/4885 |
| US-20070032478-A1 | Kinase Inhibitors | ABL1, LCK, ERBB2 | HRH3 3666/4885HRH2 3954/4885HRH1 3534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.