Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580122 | 0.96 | AURKB (0.56) | PARP1AURKBAURKAKDRCHEK2 | |
| SCHEMBL3582849 | 0.88 | AURKB (0.58) | PARP1AURKBAURKAKDRCHEK2 | |
| SCHEMBL6806441 | 0.88 | AURKB (0.70) | PARP1AURKBAURKAKDRCHEK2 | |
| SCHEMBL3582854 | 0.85 | AURKB (0.70) | PARP1AURKBAURKAKDRCHEK2 | |
| SCHEMBL3585484 | 0.85 | PARP1 (0.75) | PARP1AURKBAURKAKDRDHODH | |
| SCHEMBL3578629 | 0.85 | AURKB (0.64) | PARP1AURKBAURKAKDRCHEK2 | |
| SCHEMBL5620788 | 0.85 | AURKA (0.49) | PARP1AURKBAURKAKDRUSP2 | |
| SCHEMBL3582282 | 0.84 | AURKB (0.61) | PARP1AURKBAURKAKDRCHEK2 | |
| SCHEMBL6805222 | 0.84 | AURKA (0.75) | PARP1AURKBAURKAKDRCHEK2 | |
| SCHEMBL3577227 | 0.83 | AURKA (0.53) | PARP1AURKBAURKACHEK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |