Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.47 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805384 | 0.88 | CLK4 (0.44) | ALDH1A1KDM4ESMN1; SMN2DYRK3MAP4K4 | |
| SCHEMBL3582877 | 0.83 | PARP1 (0.69) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL6806567 | 0.83 | CHEK2 (0.42) | KDM4EDYRK3MAP4K4PIM1RPS6KB1 | |
| SCHEMBL8648025 | 0.82 | PARP1 (0.67) | PARP1GUSBPDE5ACHEK2 | |
| SCHEMBL3586495 | 0.82 | ADORA2A (0.56) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL3577822 | 0.80 | MAP4K4 (0.72) | ALDH1A1KDM4EDYRK3MAP4K4PIM1 | |
| SCHEMBL6810124 | 0.79 | CLK4 (0.47) | ALDH1A1KDM4EDYRK3MAP4K4PIM1 | |
| SCHEMBL6809867 | 0.76 | CLK4 (0.42) | ALDH1A1KDM4EDYRK3MAP4K4PIM1 | |
| SCHEMBL6799887 | 0.75 | KDM4E (0.44) | ALDH1A1KDM4EDYRK3MAP4K4PIM1 | |
| SCHEMBL4212045 | 0.75 | LMNA (0.63) | ALDH1A1KDM4ESMN1; SMN2PARP1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |