Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4679278 | 0.88 | IGF1R (0.37) | IGF1RPOLBMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL4679791 | 0.81 | BLM (0.37) | IGF1RCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3591482 | 0.81 | IGF1R (0.40) | IGF1R | |
| SCHEMBL14066488 | 0.79 | PSEN1 (0.43) | IGF1RCYP3A4CYP2C19 | |
| SCHEMBL4686158 | 0.78 | IGF1R (0.33) | IGF1RPOLBSMN1; SMN2HTTJAK2 | |
| SCHEMBL3586930 | 0.78 | IGF1R (0.41) | IGF1RMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4686151 | 0.78 | IGF1R (0.33) | IGF1RPOLBMAPTCYP3A4ALDH1A1 | |
| SCHEMBL4683030 | 0.78 | IGF1R (0.33) | IGF1RPOLB | |
| SCHEMBL4680699 | 0.77 | POLB (0.48) | POLBMAPTTHRBSMN1; SMN2CYP1A2 | |
| SCHEMBL4680635 | 0.77 | IGF1R (0.32) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075984-A1 | DICARBONYLIC COMPOUNDS WITH ANTIBACTERIAL ACTIVITY | LABORATORIOS SALVAT, S.A. (ES) | 2010-03-25 | — | — | US | disclosed |
| EP-1976837-A1 | DICARBONYLIC COMPOUNDS WITH ANTIBACTERIAL ACTIVITY | Laboratorios SALVAT, S.A. (ES) | 2008-10-08 | — | — | EP | disclosed |
| EP-1437349-B9 | SUBSTITUTED ISOXAZOLES AND THE USE THEREOF AS ANTIBIOTICS | S A L V A T LAB SA (ES) | 2008-09-10 | — | — | EP | disclosed |
| EP-1437349-B1 | SUBSTITUTED ISOXAZOLES AND THE USE THEREOF AS ANTIBIOTICS | S A L V A T LAB SA (ES) | 2007-08-15 | — | — | EP | disclosed |
| WO-2007082910-A1 | DICARBONYLIC COMPOUNDS WITH ANTIBACTERIAL ACTIVITY | LABORATORIOS SALVAT, S.A. (ES) | 2007-07-26 | — | — | WO | disclosed |
| US-20050014806-A1 | Substituted isoxazoles and their use as antibiotics | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2005-01-20 | — | — | US | disclosed |
| EP-1437349-A1 | SUBSTITUTED ISOXAZOLES AND THE USE THEREOF AS ANTIBIOTICS | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2004-07-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075984-A1 | DICARBONYLIC COMPOUNDS WITH ANTIBACTERIAL ACTIVITY | AHR, DDC, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | IGF1R 2449/4885POLB 568/4885MAPT 3754/4885 |
| US-20050014806-A1 | Substituted isoxazoles and their use as antibiotics | XDH, SCO2, HAX1 | IGF1R 798/4885POLB 1162/4885MAPT 4610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.