Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4652342 | 0.73 | CES2 (0.37) | CES2CA2 | |
| SCHEMBL6408848 | 0.73 | CA2 (0.33) | CES2CA2 | |
| SCHEMBL6901669 | 0.73 | CA2 (0.33) | CES2CA2 | |
| SCHEMBL5862766 | 0.73 | CA2 (0.33) | CES2CA2 | |
| SCHEMBL11674434 | 0.73 | CES2 (0.37) | CES2CA2 | |
| SCHEMBL26089480 | 0.73 | ALDH1A1 (0.33) | CES2CA2 | |
| SCHEMBL5327070 | 0.73 | CES2 (0.37) | CES2CA2 | |
| Methyl Alcohol SCHEMBL11878933 | 0.72 | CES2 (0.40) | CES2CA2 | |
| Fluoromethane SCHEMBL27825764 | 0.72 | CES2 (0.40) | CES2CA2 | |
| SCHEMBL344 | 0.71 | CA2 (0.41) | CES2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000022-B2 | Imidazole based LXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2015-04-07 | — | — | US | disclosed |
| EP-1910308-B1 | IMIDAZOLE BASED LXR MODULATORS | EXELIXIS PATENT CO LLC (US) | 2014-09-03 | — | — | EP | disclosed |
| US-20140038964-A1 | IMIDAZOLE BASED LXR MODULATORS | EXELIXIS PATENT COMPANY LLC (US) | 2014-02-06 | — | — | US | disclosed |
| US-8569352-B2 | Imidazole based LXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2013-10-29 | — | — | US | disclosed |
| US-20100075964-A1 | IMIDAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| EP-0850227-B1 | PYRIDAZIN-3-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION | SUMITOMO CHEMICAL CO (JP) | 2008-01-09 | — | — | EP | disclosed |
| US-20070105900-A1 | Pharmaceutical compounds | ATEX THERAPEUTICS, LIMITED (GB) | 2007-05-10 | — | — | US | disclosed |
| WO-2006070202-A1 | PYRAZOLE DERIVATIVES HAVING KINASE MODULATING ACTIVITY | ASTEX THERAPEUTICS LIMITED (GB) | 2006-07-06 | — | — | WO | disclosed |
| EP-1648449-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Astex Therapeutics Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| US-6869913-B1 | Pyridazin-3-one derivatives, their use and intermediates for their production | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-03-22 | — | — | US | disclosed |
| WO-2005002576-A2 | IMIDAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASES INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |
| US-6703503-B2 | HERBICIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-03-09 | — | — | US | disclosed |
| US-20040005986-A1 | Pyridazin-3-one derivatives, their use, and intermediates for their production | SUMITOMO CHEMICAL COMPANY, LIMITED | 2004-01-08 | — | — | US | disclosed |
| US-6482773-B1 | Pyridazin-3-one derivatives, their use, and intermediates for their production | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2002-11-19 | — | — | US | disclosed |
| US-6348628-B1 | HYDRAZONE HERBICIDE INTERMEDIATES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2002-02-19 | — | — | US | disclosed |
| US-6090753-A | 2-(SUBSTITUTED PHENYL), 5-HALOALKYL-PYRIDAZIN-3-ONE DERIVATIVES AS HERBICIDES; CONTROLLING WEEDS, METHOD OF MAKING BY REACTING A HYDRAZONE DERIVATIVE WITH A SPECIFIED PHOSPHORUS COMPOUND | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2000-07-18 | — | — | US | disclosed |
| EP-0850227-A1 | PYRIDAZIN-3-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997007104-A1 | PYRIDAZIN-3-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040005986-A1 | Pyridazin-3-one derivatives, their use, and intermediates for their production | Q6ZSR9, HDHD5, CBR3 | CES2 550/4885CA2 1952/4885ACHE 277/4885 |
| US-20140038964-A1 | IMIDAZOLE BASED LXR MODULATORS | NR1H2, NR1H3, NR1H4 | CES2 1876/4885CA2 2954/4885ACHE 3022/4885 |
| US-20100075964-A1 | IMIDAZOLE BASED LXR MODULATORS | NR1H2, NR1H3, NR1I2 | CES2 1026/4885CA2 3228/4885ACHE 3033/4885 |
| US-20070105900-A1 | Pharmaceutical compounds | AURKA, AURKC, CDK1 | CES2 3154/4885CA2 1598/4885ACHE 3733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.