Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | GRK5 | P34947 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.33 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3573419 | 0.91 | GRM2 (0.39) | GRM2GRM3LMNAEPHX1S1PR1 | |
| SCHEMBL3573137 | 0.87 | LMNA (0.35) | LMNAS1PR1S1PR5PIM1PDGFRA | |
| SCHEMBL3574585 | 0.84 | LMNA (0.42) | GRM2GRM3LMNAEPHX1S1PR1 | |
| SCHEMBL3581012 | 0.79 | HDAC8 (0.37) | GRM2GRM3LMNAEPHX1S1PR1 | |
| SCHEMBL3580280 | 0.79 | DCUN1D1 (0.36) | LMNAS1PR1S1PR5GRK5CDK8 | |
| SCHEMBL3581040 | 0.79 | STAT3 (0.39) | EPHX1KCNH2CNR1 | |
| SCHEMBL3584408 | 0.77 | MEN1 (0.39) | LMNAS1PR1S1PR5GRK5CDK8 | |
| SCHEMBL3576637 | 0.77 | LMNA (0.41) | LMNAS1PR1S1PR5PIM1PDGFRA | |
| SCHEMBL3583574 | 0.76 | HSD11B1 (0.34) | LMNAS1PR1S1PR5GRK5CDK8 | |
| SCHEMBL27750941 | 0.75 | MCL1 (0.37) | LMNAS1PR1S1PR5GRK5CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |