Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 7/20 | 0.37 |
| ▸ | UBE2M | P61081 | 6/20 | 0.37 |
| ▸ | STAT3 | P40763 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580280 | 0.92 | DCUN1D1 (0.36) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3573137 | 0.92 | LMNA (0.35) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3586114 | 0.89 | LMNA (0.41) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3583574 | 0.88 | HSD11B1 (0.34) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3581091 | 0.88 | STAT3 (0.39) | DCUN1D1UBE2MSTAT3CNR1 | |
| SCHEMBL3573419 | 0.86 | GRM2 (0.39) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3579273 | 0.86 | LMNA (0.37) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27750941 | 0.84 | MCL1 (0.37) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27750967 | 0.82 | S1PR1 (0.39) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3577153 | 0.82 | LMNA (0.42) | MEN1LMNACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |