Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10172648 | 0.90 | PARP1 (0.41) | PARP1PARP2KMT2ACNR1RPS6KB1 | |
| SCHEMBL358333 | 0.89 | PARP1 (0.48) | PARP1PARP2CCNA2CDK2CCNA1 | |
| Hydrochloric Acid SCHEMBL357948 | 0.84 | RPS6KB1 (0.48) | PARP1PARP2RPS6KB1AURKA | |
| SCHEMBL359223 | 0.84 | PARP1 (0.49) | PARP1 | |
| SCHEMBL370739 | 0.79 | PARP1 (0.46) | PARP1KMT2A | |
| SCHEMBL27899434 | 0.76 | ADRA1A (0.37) | CCNA2CDK2CCNA1KMT2ACNR1 | |
| SCHEMBL370599 | 0.76 | PARP1 (0.46) | PARP1 | |
| SCHEMBL10173016 | 0.74 | PARP1 (0.51) | PARP1PARP2KMT2ARPS6KB1AURKA | |
| SCHEMBL359581 | 0.71 | RPS6KB1 (0.48) | PARP1PARP2RPS6KB1AURKA | |
| SCHEMBL358670 | 0.69 | PARP1 (0.52) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | claimed |
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |