Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.50 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5177646 | 0.91 | MAPK14 (0.53) | MAPK14DGAT2FFAR2ROCK2ROCK1 | |
| SCHEMBL3272257 | 0.88 | EPHX2 (0.60) | MAPK14DGAT2FFAR2ROCK2ROCK1 | |
| SCHEMBL3581264 | 0.84 | HTR2C (0.53) | MAPK14DGAT2FFAR2ROCK2ROCK1 | |
| SCHEMBL3572811 | 0.83 | BACE1 (0.60) | MAPK14BACE1NPC1ALDH1A1RAB9A | |
| SCHEMBL5177429 | 0.82 | MAPK14 (0.48) | MAPK14DGAT2FFAR2ROCK2ROCK1 | |
| SCHEMBL5175891 | 0.81 | BACE1 (0.58) | MAPK14HTR2CEPHX2LTA4HNR1H4 | |
| SCHEMBL3584103 | 0.77 | KDM4E (0.47) | MAPK14EPHX2LTA4HNPC1CETP | |
| SCHEMBL24439970 | 0.77 | KIF11 (0.54) | MAPK14DGAT2FFAR2ROCK2ROCK1 | |
| SCHEMBL29606146 | 0.77 | KIF11 (0.54) | MAPK14DGAT2FFAR2ROCK2ROCK1 | |
| SCHEMBL21981021 | 0.77 | AOC2 (0.51) | MAPK14FFAR2ROCK2ROCK1GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |