Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | VNN1 | O95497 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | GLS | O94925 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3272257 | 0.88 | EPHX2 (0.60) | MAPK14EPHX2NR1H4DGAT2VNN1 | |
| SCHEMBL3578662 | 0.86 | BACE1 (0.56) | MAPK14DGAT2NPC1PPARAMAPT | |
| SCHEMBL5177646 | 0.84 | MAPK14 (0.53) | HTR2CMAPK14EPHX2NR1H4LTA4H | |
| SCHEMBL3584100 | 0.84 | MAPK14 (0.53) | HTR2CMAPK14EPHX2NR1H4LTA4H | |
| SCHEMBL5175891 | 0.83 | BACE1 (0.58) | HTR2CMAPK14EPHX2NR1H4LTA4H | |
| SCHEMBL5177429 | 0.82 | MAPK14 (0.48) | HTR2CMAPK14EPHX2LTA4HDGAT2 | |
| SCHEMBL934551 | 0.79 | GLS (0.61) | MAPK14EPHX2ROCK2ROCK1GLS | |
| SCHEMBL3586612 | 0.79 | LMNA (0.65) | NPC1PPARASMN1; SMN2 | |
| SCHEMBL23652001 | 0.79 | VNN1 (0.51) | MAPK14DGAT2NLRP3VNN1ROCK2 | |
| SCHEMBL29605543 | 0.78 | MMP13 (0.55) | MAPK14DGAT2NPC1ROCK2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |