Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.34 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 7/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587697 | 0.90 | C5AR1 (0.41) | C5AR1LPAR1LPAR2HSP90AA1LPAR5 | |
| SCHEMBL3577159 | 0.90 | C5AR1 (0.42) | C5AR1LPAR1LPAR2HSP90AA1LPAR5 | |
| SCHEMBL3576449 | 0.86 | LPAR1 (0.39) | C5AR1LPAR1LPAR2LPAR5NLRP3 | |
| SCHEMBL3580626 | 0.83 | LMNA (0.40) | C5AR1LPAR1LPAR5LMNAKMT2A | |
| SCHEMBL3583345 | 0.83 | C5AR1 (0.40) | C5AR1LPAR1LPAR2LPAR5NPC1 | |
| SCHEMBL27750937 | 0.83 | C5AR1 (0.40) | C5AR1LPAR1LPAR2LPAR5NLRP3 | |
| SCHEMBL3581908 | 0.82 | NLRP3 (0.41) | C5AR1LPAR1LPAR2LPAR5NLRP3 | |
| SCHEMBL3586617 | 0.82 | C5AR1 (0.41) | C5AR1LPAR1LPAR2HSP90AA1LPAR5 | |
| SCHEMBL3571491 | 0.82 | C5AR1 (0.42) | C5AR1LPAR1LPAR2HSP90AA1LPAR5 | |
| SCHEMBL3580698 | 0.82 | C5AR1 (0.44) | C5AR1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |